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Born near Callander and graduated in medicine at the University of Edinburgh. He became a physician, and succeeded Roxburgh briefly at the Calcutta Botanic Garden, but returned to Scotland to establish his right to be head of Clan Buchanan. Francis Hamilton (né Buchanan) changed his name to “Hamilton” to fulfil the requirements of a legacy. Buchanan Hamilton contributed greatly as a botanist, zoologist and geographer in India. He was the first botanist to see Pinus excelsa and Juniperus recurva.